Whole-cell simulation: a grand challenge of the 21st century

M Tomita - TRENDS in Biotechnology, 2001 - cell.com
… However, it has been demonstrated in intensive gene-knock-out studies by The Institute
for Genomic Research (TIGR) that many of the 480 genes are not always necessary for M. …

Twenty-five years of research on bovine lactoferrin applications

M Tomita, H Wakabayashi, K Shin, K Yamauchi… - Biochimie, 2009 - Elsevier
Lactoferrin (LF) was identified as a milk protein in 1960. Large-scale manufacturing of
bovine LF (bLF) was established more than 20 years ago. Using this commercially available …

Bovine lactoferrin and lactoferricin derived from milk: production and applications

M Tomita, H Wakabayashi, K Yamauchi… - … and Cell Biology, 2002 - cdnsciencepub.com
Bovine lactoferrin is produced on an industrial scale from cheese whey or skim milk. The safety
of purified lactoferrin has been confirmed from the results of a reverse mutation test using …

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

…, Y Nakano, K Tobe, R Nagai, S Kimura, M Tomita… - Nature medicine, 2001 - nature.com
Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a
susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where …

Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection

…, M Baba, KA Datsenko, M Tomita… - Molecular systems …, 2006 - embopress.org
We have systematically made a set of precisely defined, single‐gene deletions of all
nonessential genes in Escherichia coli K‐12. Open‐reading frame coding regions were replaced …

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models

…, HD Spence, J Stelling, K Takahashi, M Tomita… - …, 2003 - academic.oup.com
Motivation: Molecular biotechnology now makes it possible to build elaborate systems
models, but the systems biology community needs information standards if models are to be …

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

…, T Lockett, JM Clarke, DL Topping, M Tomita… - Nature, 2013 - nature.com
Gut commensal microbes shape the mucosal immune system by regulating the differentiation
and expansion of several types of T cell 1 , 2 , 3 , 4 , 5 . Clostridia, a dominant class of …

High-temperature superconductor bulk magnets that can trap magnetic fields of over 17 tesla at 29 K

M Tomita, M Murakami - Nature, 2003 - nature.com
Large-grain high-temperature superconductors of the form RE-Ba-Cu-O (where RE is a rare-earth
element) can trap magnetic fields of several tesla at low temperatures, and so can be …

Universals and cultural differences in the judgments of facial expressions of emotion.

…, PE Ricci-Bitti, K Scherer, M Tomita… - Journal of personality …, 1987 - psycnet.apa.org
We present here new evidence of cross-cultural agreement in the judgment of facial expression.
Subjects in 10 cultures performed a more complex judgment task than has been used in …

[BOOK][B] Efficient parsing for natural language: a fast algorithm for practical systems

M Tomita - 1985 - books.google.com
… Finally, I wish to thank Yuko Tomita for many discussions on linguistic aspects of my work,
and more importantly, for her continuous encouragement and emotional support. Yuko always …