Purpose To test the hypothesis—given the increasing emphasis on quantitative computed
tomographic (CT) phenotypes of chronic obstructive pulmonary disease (COPD)—that a …

Rationale: Idiopathic pulmonary fibrosis (IPF) and other idiopathic interstitial pneumonias (IIPs)
have similar clinical and radiographic features, but their histopathology, response to …

Objective To examine the efficacy of methotrexate monotherapy relative to etanercept
monotherapy and the value of combining methotrexate and etanercept for the treatment of patients …

Lung CD8+ T cells might contribute to progression of chronic obstructive pulmonary disease
(COPD) indirectly via IFN-γ production or directly via cytolysis, but evidence for either …

Background The value of quantitative CT (QCT) to identify chronic obstructive pulmonary
disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that QCT-…

Rationale: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea,
impaired gas exchange, and ultimate mortality. Objectives: To test the hypothesis that maximal …

COPD is a heterogeneous disorder with clinical assessment becoming increasingly
multidimensional. We hypothesized HRCT phenotype would strongly influence clinical outcomes …

Rationale: Bronchoalveolar lavage fluid (BAL) from human lung allografts demonstrates the
presence of a multipotent mesenchymal stromal cell population. However, the clinical …

Objective In this post hoc analysis, we examined the potential impact of sex and BMI on
response in the Study of Etanercept and Methotrexate in Combination or as Monotherapy in …

BACKGROUND: HRQL in IPF patients is impaired. Data from other respiratory diseases led
us to hypothesize that significant gender differences in HRQL in IPF also exist. METHODS: …