A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with
the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human …

Using the Immunochip custom SNP array, which was designed for dense genotyping of 186
loci identified through genome-wide association studies (GWAS), we analyzed 11,475 …

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic
immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and …

OBJECTIVE: To assess the influence of the TNFA rs1800629 (G>A) polymorphism in the risk
of cardiovascular (CV) disease and subclinical atherosclerosis in patients with rheumatoid …

OBJECTIVES: To describe patients with autoimmune inflammatory rheumatic diseases (AIRD)
who had COVID-19 disease; to compare patients who required hospital admission with …

Cardiovascular disease (CV) is the most common cause of premature mortality in patients
with rheumatoid arthritis (RA). This is the result of an accelerated atherosclerotic process. …

Objectives To describe patients with autoimmune inflammatory rheumatic diseases (AIRD)
who had COVID-19 disease; to compare patients who required hospital admission with those …

Objective A highly polygenic aetiology and high degree of allele-sharing between ancestries
have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-…

Background In recent years, research has consistently proven the occurrence of genetic
overlap across autoimmune diseases, which supports the existence of common pathogenic …