User profiles for Luis Graca
 | Luis GracaIMM, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa Verified email at fm.ul.pt Cited by 10080 |
Identification of regulatory T cells in tolerated allografts
Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal
antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4 + T …
antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4 + T …
Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells
Follicular helper T (T FH) cells participate in humoral responses providing selection signals
to germinal center B cells. Recently, expression of CXCR5, PD-1, and the transcription factor …
to germinal center B cells. Recently, expression of CXCR5, PD-1, and the transcription factor …
Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
…, R Castejon, E Adams, D Zelenika, L Graca… - The Journal of …, 2004 - journals.aai.org
Transplantation tolerance can be induced in mice by grafting under the cover of nondepleting
CD4 plus CD8 or CD154 mAbs. This tolerance is donor Ag specific and depends on a …
CD4 plus CD8 or CD154 mAbs. This tolerance is donor Ag specific and depends on a …
Both CD4+ CD25+ and CD4+ CD25− regulatory cells mediate dominant transplantation tolerance
CD4+ CD25+ T cells have been proposed as the principal regulators of both self-tolerance
and transplantation tolerance. Although CD4+ CD25+ T cells do have a suppressive role in …
and transplantation tolerance. Although CD4+ CD25+ T cells do have a suppressive role in …
[HTML][HTML] Risk of BA. 5 infection among persons exposed to previous SARS-CoV-2 variants
…, VR Fonseca, MC Gomes, L Graca - … England Journal of …, 2022 - Mass Medical Soc
Protection against Omicron BA.5 from Previous Infection Conventional wisdom is that previous
infection with omicron subvariant BA.1 or BA.2 does not protect against BA.5, but data …
infection with omicron subvariant BA.1 or BA.2 does not protect against BA.5, but data …
[HTML][HTML] Regulation of the germinal center response
…, VR Fonseca, MA Linterman, L Graca - Frontiers in …, 2018 - frontiersin.org
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can …
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can …
Sexuality during pregnancy
JR Pauleta, NM Pereira, LM Graça - The journal of sexual …, 2010 - academic.oup.com
Introduction Sexuality is an important part of health and well-being. Sexual behavior modifies
as pregnancy progresses, influenced by biological, psychological, and social factors. Aim …
as pregnancy progresses, influenced by biological, psychological, and social factors. Aim …
[HTML][HTML] T follicular helper and T follicular regulatory cells have different TCR specificity
Immunization leads to the formation of germinal centres (GCs) that contain both T follicular
helper (Tfh) and T follicular regulatory (Tfr) cells. Whether T-cell receptor (TCR) specificity …
helper (Tfh) and T follicular regulatory (Tfr) cells. Whether T-cell receptor (TCR) specificity …
In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune …
…, A Salgado, M Videira, M Gaspar, L Graca… - Journal of Controlled …, 2015 - Elsevier
We hypothesized that the co-entrapment of melanoma-associated antigens and the Toll-like
receptor (TLR) ligands Poly(I:C) and CpG, known to be Th1-immunopotentiators, in …
receptor (TLR) ligands Poly(I:C) and CpG, known to be Th1-immunopotentiators, in …
Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-β
…, I Wollenberg, B Silva-Santos, L Graca - The Journal of …, 2010 - journals.aai.org
Invariant NKT (iNKT) cells were shown to prevent the onset of experimental autoimmune
encephalomyelitis in mice following administration of their specific TCR agonist α-…
encephalomyelitis in mice following administration of their specific TCR agonist α-…