We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic
immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and …

Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjögren’s
syndrome are four major autoimmune rheumatic diseases characterized by the presence of …

Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients with
a single gene defect. This rare variant of lupus generally presents with early onset severe …

The entry of SARS-CoV-2 into host cells is dependent upon angiotensin-converting enzyme
2 (ACE2), which serves as a functional attachment receptor for the viral spike glycoprotein, …

Objectives Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the
interplay between both genetic and epigenetic factors. Monocytes are crucial players of the …

Introduction According to genome wide association (GWA) studies as well as candidate
gene approaches, Behçet’s disease (BD) is associated with human leukocyte antigen (HLA)-A …

Behcet's disease (BD) is an immuno-mediated vasculitis in which knowledge of its etiology
and genetic basis is limited. To improve the current knowledge, a genetic analysis performed …

Objective: Henoch-Schönlein purpura (HSP) is the most common vasculitis in children but it
is not exceptional in adults. Increased familial occurrence supports a genetic predisposition …

Introduction A study was conducted to determine whether the human leukocyte antigen (HLA)
B alleles are implicated in the susceptibility to Henoch-Schönlein purpura (HSP) in the …

Objectives Behçet's disease tends to be more severe in men than women. This study was
undertaken to investigate sex-specific genetic effects in Behçet's disease. Methods A total of …