Background Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis
that is poorly understood. We identified six families with multiple cases of systemic and …

Objectives: To examine the efficacy of aciclovir suspension for treating herpetic gingivostomatitis
in young children. Design: Randomised double blind placebo controlled study. Setting: …

Background To our knowledge, the characteristics and burden of childhood arthritis have
never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional study…

OBJECTIVE: To determine the prevalence of neuropsychiatric (NP) manifestations in
children with systemic lupus erythematosus (SLE) using the 1999 American College of …

Objective In pivotal trials, canakinumab has been shown to be effective in the treatment of
systemic juvenile idiopathic arthritis (JIA), but reported adverse events have included …

Background Juvenile idiopathic arthritis can be refractory to some or all treatment regimens,
therefore new medications are needed to treat this population. This trial assessed the …

We performed a prospective, randomized, open-label equivalence study comparing the use
of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of …

The production of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and IL-10 by peripheral
blood mononuclear cells was examined in 13 children with and 11 children without any …

Background Canakinumab is a human anti-interleukin-1β (IL-1β) monoclonal antibody
neutralizing IL-1β-mediated pathways. We sought to characterize the molecular response to …

… Liora Harel and Dario Prais contributed equally to this work as first authors. Reprints: Liora
Harel, MD, Department of Pediatrics C, … Other articles in this journal by Liora Harel, MD …