Deficiency of early components of the classical pathway of complement, particularly C1q,
predisposes to the development of systemic lupus erythematosus. Several studies have …

Autoimmune responses against posttranslationally modified antigens are a hallmark of
several autoimmune diseases. For example, antibodies against citrullinated protein antigens (…

In animals, immunomodulatory dendritic cells (DCs) exposed to autoantigen can suppress
experimental arthritis in an antigen-specific manner. In rheumatoid arthritis (RA), disease-…

Anti-C1q autoantibodies are present in sera of patients with several autoimmune diseases,
including systemic lupus erythematosus (SLE). Strikingly, in SLE the presence of anti-C1q is …

Objective To determine whether anticitrullinated protein antibodies (ACPA) exhibit specific
changes in Fc glycosylation prior to the onset of arthritis. Methods Serum samples of patients …

Objective The presence of anti-citrullinated protein antibodies (ACPA) and IgM-rheumatoid
factor (IgM-RF) years before the clinical diagnosis of rheumatoid arthritis (RA) suggests they …

Objective Recently, we discovered a new autoantibody system in rheumatoid arthritis (RA):
anti–carbamylated protein (anti‐CarP) antibodies. These antibodies have value in predicting …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, and affects 0.5–1%
of the population. Although it poses a considerable health problem, relatively little …

Objective Anti–citrullinated protein antibodies (ACPA) exhibit unique specificity for rheumatoid
arthritis. However, it is incompletely understood whether and how ACPA contribute to …

Objectives To understand the molecular features distinguishing anti-citrullinated protein
antibodies (ACPA) from ‘conventional’ antibodies in rheumatoid arthritis (RA). Methods Serum of …