Vasoconstriction accompanied by changes in skin color is a normal physiologic response to
cold. The distinction between this normal physiology and Raynaud's phenomenon (RP) has …

Experience suggests that African Americans may express autoimmune disease differently
than other racial groups. In the context of systemic sclerosis (scleroderma), we sought to …

Many conditions presenting with clinical hard skin and tissue fibrosis can be confused with
systemic sclerosis (scleroderma). These disorders have very diverse etiologies and often an …

The aim of this study was to determine, through a genome-wide association study (GWAS),
the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis …

Objective Pulmonary hypertension (PH) is an important cause of mortality in systemic sclerosis
(SSc), where it can be isolated (pulmonary arterial hypertension [PAH]) or associated with …

In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with
the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human …

Background— Systemic sclerosis–associated pulmonary artery hypertension (SScPAH) has
a worse prognosis compared with idiopathic pulmonary arterial hypertension (IPAH), with a …

Rationale: Pulmonary arterial hypertension (PAH) related to systemic sclerosis (SSc) has a
poorer prognosis compared with other forms of PAH for reasons that remain unexplained. …

Objective To assess cumulative survival rates and identify independent predictors of
mortality in patients with incident systemic sclerosis (SSc)–associated pulmonary arterial …

Background— Right ventricular (RV) functional reserve affects functional capacity and
prognosis in patients with pulmonary arterial hypertension (PAH). PAH associated with systemic …