While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear,
other brain-resident myeloid cells remain less well understood. By dissecting border regions …

Nuclear factor (NF)-κB has an important role in immunity and inappropriate NF-κB activity
has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms …

Although known for many years as a nuclear factor (NF)-κB inhibitory and antiapoptotic
signaling protein, A20 has recently attracted much attention because of its ubiquitin-regulatory …

The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA) 1 . In humans, …

Receptor interacting protein kinase 1 (RIPK1) has an essential role in the signalling triggered
by death receptors and pattern recognition receptors 1 , 2 . RIPK1 is believed to function as …

A20 is a nuclear factor κB (NF-κB) target gene that encodes a ubiquitin-editing enzyme that
is essential for the termination of NF-κB activation after tumor necrosis factor (TNF) or …

A20 (TNFAIP3) is a protein that is involved in the negative feedback regulation of NF-κB
signaling in response to specific proinflammatory stimuli in different cell types and has been …

Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II hi and MHC-II
lo tumor-associated macrophage (TAM) subpopulations that originate from Ly6C hi …

Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …

The intestinal epithelium is the largest surface area of the body in contact with the external
environment. This specialized single cell layer is constantly renewed and is a physical barrier …