Background: Chronic pain remains a significant challenge for modern health care as its
pathologic mechanisms are largely unknown and preclinical animal models suffer from …

Background Recent consensus guidelines recommend pregabalin as a first-tier treatment for
painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 …

BackgroundPregabalin is a novel compound that has been shown to have efficacy in the
treatment of generalised anxiety disorder and is licensed for the treatment of the disorder in the …

Purpose: To determine maximum tolerated dose of CI-994, a novel oral histone deacetylase
inhibitor, in combination with carboplatin and paclitaxel in patients with advanced solid …

Objective. To evaluate the efficacy and safety of pregabalin monotherapy versus placebo for
symptomatic pain relief and improvement of patient global assessment in patients with …

… David Semel and Lynne Pauer are employees of Pfizer and have stock or stock options
with Pfizer. Medical writing support was provided by David Cope, PhD, of Engage Scientific …

Objectives: This study used a randomized withdrawal design to evaluate the efficacy of
pregabalin versus placebo for pain relief in patients with painful diabetic peripheral neuropathy …

Background Fibromyalgia (FM) is a common pain condition characterized by widespread
musculoskeletal pain and tenderness. Pregabalin is an approved treatment for adults in the …

Objective. To assess pregabalin efficacy and safety in patients with fibromyalgia (FM) with
comorbid depression taking concurrent antidepressant medication. Methods. This randomized…

Objectives: Pregabalin, an α2-δ agonist, is approved for the treatment of fibromyalgia (FM) in
the United States, Japan, and 37 other countries. The purpose of this article was to provide …