Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial …
…, D Baeten, T Baker, M Griffiths, L Ionescu… - Annals of the …, 2018 - ard.bmj.com
Objective Interleukin (IL)-17A has emerged as pivotal in driving tissue pathology in immune-mediated
inflammatory diseases. The role of IL-17F, sharing 50% sequence homology and …
inflammatory diseases. The role of IL-17F, sharing 50% sequence homology and …
Head-to-head comparison of certolizumab pegol versus adalimumab in rheumatoid arthritis: 2-year efficacy and safety results from the randomised EXXELERATE …
…, C Cioffi, C Ecoffet, L Gervitz, L Ionescu… - The Lancet, 2016 - thelancet.com
Background To date, head-to-head trials comparing the efficacy and safety of biological
disease-modifying antirheumatic drugs within the same class, including TNF inhibitors, in …
disease-modifying antirheumatic drugs within the same class, including TNF inhibitors, in …
Efficacy and safety of bimekizumab in moderate to severe hidradenitis suppurativa: a phase 2, double-blind, placebo-controlled randomized clinical trial
…, R Rolleri, S Seegobin, D Baeten, L Ionescu… - JAMA …, 2021 - jamanetwork.com
Importance Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a high
burden for patients and limited existing therapeutic options. Objective To evaluate the efficacy …
burden for patients and limited existing therapeutic options. Objective To evaluate the efficacy …
Increasing stability of crew and aircraft schedules
Stability describes the grade of the ability of a plan to remain feasible and cost efficient under
variations of the operating environment without major modifications to the plan. In airline …
variations of the operating environment without major modifications to the plan. In airline …
Timing and magnitude of initial change in disease activity score 28 predicts the likelihood of achieving low disease activity at 1 year in rheumatoid arthritis patients …
Objective. To determine the relationship between timing and magnitude of Disease Activity
Score [DAS28(ESR)] nonresponse (DAS28 improvement thresholds not reached) during the …
Score [DAS28(ESR)] nonresponse (DAS28 improvement thresholds not reached) during the …
Efficacy and safety of bimekizumab as add-on therapy for rheumatoid arthritis in patients with inadequate response to certolizumab pegol: a proof-of-concept study
…, G Schett, R Landewé, D Baeten, L Ionescu… - Annals of the …, 2019 - ard.bmj.com
Objective Evaluate the efficacy and safety of dual neutralisation of interleukin (IL)-17A and IL-17F
with bimekizumab, a monoclonal IgG1 antibody, in addition to certolizumab pegol (CZP…
with bimekizumab, a monoclonal IgG1 antibody, in addition to certolizumab pegol (CZP…
Increasing flexibility of airline crew schedules
Airline transportation frequently has to deal with disruptions, like technical breakdowns or
bad weather conditions. Resulting delays often lead to additional delays, due to …
bad weather conditions. Resulting delays often lead to additional delays, due to …
Mode Switching Is the Major Mechanism of Ligand Regulation of InsP3 Receptor Calcium Release Channels
The inositol 1,4,5-trisphosphate (InsP 3 ) receptor (InsP 3 R) plays a critical role in generation
of complex Ca 2+ signals in many cell types. In patch clamp recordings of isolated nuclei …
of complex Ca 2+ signals in many cell types. In patch clamp recordings of isolated nuclei …
Graded recruitment and inactivation of single InsP3 receptor Ca2+‐release channels: implications for quartal Ca2+release
Modulation of cytoplasmic free Ca 2 + concentration ([Ca 2 + ] i ) by receptor‐mediated
generation of inositol 1,4,5‐trisphosphate (InsP 3 ) and activation of its receptor (InsP 3 R), a Ca 2 …
generation of inositol 1,4,5‐trisphosphate (InsP 3 ) and activation of its receptor (InsP 3 R), a Ca 2 …
Data analysis of delays in airline networks
Cost-optimized airline resource schedules often imply a lack of delay tolerance in case of
unforeseen disruptions, eg late check-ins, technical defects or airport and airspace congestion. …
unforeseen disruptions, eg late check-ins, technical defects or airport and airspace congestion. …