Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers,
but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor …

The mechanisms by which immune checkpoint blockade modulates tumor evolution during
therapy are unclear. We assessed genomic changes in tumors from 68 patients with …

CD8 + T cell–dependent killing of cancer cells requires efficient presentation of tumor
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to which …

Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …

Importance The rapidly expanding novel coronavirus disease 2019 (COVID-19) pandemic,
caused by severe acute respiratory syndrome coronavirus 2, has challenged the medical …

Objective: (1) Describe current epidemiology of thyroid cancer in the United States; (2) evaluate
hypothesized causes of the increased incidence of thyroid cancer; and (3) suggest next …

Despite substantial improvements in head and neck squamous cell carcinoma (HNSCC)
treatment, the major obstacle to long‐term survival remains disease recurrence. Salvage …

Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood. …

Recent clinical trials have demonstrated a clear survival advantage in advanced head and
neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade. …

Background: The rapidly rising incidence of papillary thyroid cancer may be due to
overdiagnosis of a reservoir of subclinical disease. To conclude that overdiagnosis is occurring, …