Medical Education 2012: 46: 357–365 Context Current debate in medical education focuses
on the nature of ‘competency‐based medical education’ (CBME) and whether or not it …

Osteoporosis is the most common cause of fragility fractures. Bone remodelling is essential
for repairing damaged areas within bone to preserve bone strength and for assisting in …

Bone structure is an integral determinant of bone strength. The availability of high resolution
peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure …

Objective To outline the efficacy and risks of bisphosphonate therapy for the management of
osteoporosis and describe which patients might be eligible for bisphosphonate “drug …

In 2003, the first reports describing osteonecrosis of the jaw (ONJ) in patients receiving
bisphosphonates (BP) were published. These cases occurred in patients with cancer receiving …

Transiliac bone biopsies were obtained from 55 women treated with teriparatide or placebo
for 12–24 months. We report direct evidence that modeling bone formation at quiescent …

Context: Biochemical markers of bone turnover may reflect bone structure during anabolic
treatment. Objective: The objective was to evaluate associations between changes in …

Interferon γ (IFN‐γ) is a cytokine produced locally in the bone microenvironment by cells of
immune origin as well as mesenchymal stem cells. However, its role in normal bone …

We previously reported that urokinase (uPA) is produced by the human prostate cancer cell
line, PC-3, and could function as a growth factor for cells of the osteoblast phenotype. To …

Hajdu‐Cheney syndrome (HCS) is a rare genetic disorder whose hallmark is acro‐osteolysis,
shortening of terminal phalanges, and generalized osteoporosis. We assembled a cohort …