The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the T H 17
subset of helper T cells remain unclear. Here we used a novel strategy for the conditional …

See Petzold (doi: 10.1093/aww239 ) for a scientific commentary on this article. Assessment
of inflammatory disease activity during multiple sclerosis is crucial for selecting appropriate …

Foxp3 + regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an
inflammatory environment presents a threat to Treg cell identity and function. Here, we …

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized
in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell …

Brain volumetric measurements in multiple sclerosis (MS) reflect not only disease-specific
processes but also other sources of variability. The latter has to be considered especially in …

Objective To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large
cohort of patients with early multiple sclerosis (MS). Methods Serum samples were collected …

Importance Clinically isolated syndrome (CIS) describes a first clinical incident suggestive of
multiple sclerosis (MS). Identifying patients with CIS who have a high risk of future disease …

Background Effector functions of IgG Abs are regulated by their Fc N-glycosylation pattern.
IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the severity …

Objective Patients with myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated
disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro‐axonal …

Progressive multi-focal leucoencephalopathy and progressive multi-focal
leucoencephalopathy-immune reconstitution inflammatory syndrome are caused by infection of the …