IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal
pathogens in experimental models. However, no human studies have demonstrated a …

BACKGROUND & AIMS: Polymorphisms in IL28B were shown to affect clearance of hepatitis
C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of …

In populations exposed to Leishmania braziliensis, certain subjects develop skin ulcers,
whereas others are naturally protected against cutaneous leishmaniasis. We have evaluated …

Immunity against schistosomes includes anti‐infection immunity, which is mainly active against
invading larvae in the skin, and anti‐disease immunity, which controls abnormal fibrosis …

In leishmaniasis, Th1-related cytokines production seems to be crucial for host control of
parasite burden and clinical cure. Visceral and diffuse cutaneous leishmaniasis are …

Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate
immunity, tissue protection, and repair. IL‐22 may also cause inflammation and abnormal …

Schistosome infection is a major public health concern affecting millions of people living in
tropical regions of Africa, Asia, and South America. Schistosomes cause mild clinical …

Millions of humans are exposed to schistosome infections, which cause severe kidney and
liver disease and 280,000 deaths annually. Th2-mediated immunity is critical to human …

A previous study performed in adolescents living in an area endemic for Schistosoma mansoni
in Brazil has shown that a 37 kDa schistosome surface antigen is a selective target for …

Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of
death in hepatitis C virus and schistosome infections. Hepatic fibrosis (HF) may develop …