Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies
LR Lard, H Visser, I Speyer… - The American journal of …, 2001 - Elsevier
PURPOSE: To compare the effect of delayed and early treatment strategies on disease
outcome in patients with rheumatoid arthritis. SUBJECTS AND METHODS: Between 1993 and …
outcome in patients with rheumatoid arthritis. SUBJECTS AND METHODS: Between 1993 and …
Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double‐blind, randomized, placebo‐controlled trial
H van Dongen, J van Aken, LR Lard… - Arthritis & …, 2007 - Wiley Online Library
Objective To determine whether patients with undifferentiated arthritis (UA; inflammatory,
nontraumatic arthritis that cannot be diagnosed using current classification criteria) benefit from …
nontraumatic arthritis that cannot be diagnosed using current classification criteria) benefit from …
Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis
…, MT Nurmohamed, CJA Doelman, LR Lard… - Annals of the …, 2003 - ard.bmj.com
Background: Glucocorticoids induce hypercholesterolaemia, a cardiovascular risk factor, in
patients with diseases other than rheumatoid arthritis (RA), but the data in RA are …
patients with diseases other than rheumatoid arthritis (RA), but the data in RA are …
Neutrophil activation in sickle cell disease
LR Lard, FPJ Mul, M De Haas, D Roos… - Journal of leukocyte …, 1999 - academic.oup.com
Vascular occlusion is the main cause of the morbidity and mortality observed in patients with
sickle cell disease (SCD). Increasing evidence indicates that (activated) neutrophils could …
sickle cell disease (SCD). Increasing evidence indicates that (activated) neutrophils could …
Matrix metalloproteinases-3,-8,-9 as markers of disease activity and joint damage progression in early rheumatoid arthritis
I Tchetverikov, LR Lard, J DeGroot, N Verzijl… - Annals of the …, 2003 - ard.bmj.com
Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix
metalloproteinase (MMP) activity in α 2 macroglobulin (α 2 M)/MMP complexes and the …
metalloproteinase (MMP) activity in α 2 macroglobulin (α 2 M)/MMP complexes and the …
Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis
J van Aken, LR Lard, S le Cessie… - Annals of the …, 2004 - ard.bmj.com
Objective: To determine the effect of different treatment strategies (early versus delayed) on
the radiological progression of joint damage during 4 years. Additionally, to determine the …
the radiological progression of joint damage during 4 years. Additionally, to determine the …
New concepts in assessing sickle cell disease severity
JJB Schnog, LR Lard, RA Rojer… - American journal of …, 1998 - Wiley Online Library
Vasoocclusion leads to pain, chronic organ damage, and a decreased life expectancy in
patients with sickle cell disease. Therapeutic options for sickle cell disease have usually been …
patients with sickle cell disease. Therapeutic options for sickle cell disease have usually been …
Clinical and radiological outcomes of 5-year drug-free remission-steered treatment in patients with early arthritis: IMPROVED study
…, AJ Peeters, GM Steup-Beekman, LR Lard… - Annals of the …, 2018 - ard.bmj.com
Objectives To determine the 5-year outcomes of early remission induction therapy followed
by targeted treatment aimed at drug-free remission (DFR) in patients with early arthritis. …
by targeted treatment aimed at drug-free remission (DFR) in patients with early arthritis. …
Elevated IL‐8 levels during sickle cell crisis
AJ Duits, JB Schnog, LR Lard… - European journal of …, 1998 - Wiley Online Library
The vaso‐occlusive process (VOC) in sickle cell disease is of a complex nature. It involves
intricate interactions between sickle red blood cells, endothelium and probably also …
intricate interactions between sickle red blood cells, endothelium and probably also …
Association of the–2849 interleukin‐10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis
LR Lard, FA Van Gaalen… - … : Official Journal of …, 2003 - Wiley Online Library
Objective To analyze the –2849 A/G interleukin‐10 (IL‐10) promoter polymorphism, which
is associated with high (AG/GG) and low (AA) IL‐10 production, in a cohort of rheumatoid …
is associated with high (AG/GG) and low (AA) IL‐10 production, in a cohort of rheumatoid …