Purpose Our aim was to perform a systematic review of the methods currently being used to
assess adherence and persistence in pharmacoepidemiological and pharmacoeconomic …

In alignment with the International Council of Harmonization’s strategic goals, a public-private
consortium has developed a structured template for planning and reporting on the …

Objective: The aim of this study was to quantify the magnitude of risk reduction for venous
thromboembolism events associated with an estradiol transdermal system relative to oral …

OBJECTIVE—In Canada, diabetes poses a significant health problem, and current estimates
of its economic burden have not incorporated the total cost of the disease. The objective of …

Evidence-based health care decisions are best informed by comparisons of all relevant
interventions used to treat conditions in specific patient populations. Observational studies are …

Background & Aims: Constipation is a multisymptom disorder that frequently compromises
quality of life and leads patients to seek medical advice. To evaluate the clinical and fiscal …

Background The use of inhaled corticosteroids in patients with chronic obstructive pulmonary
disease (COPD) has been associated with an increased risk of pneumonia in controlled …

Although the analysis of ‘big data’ holds tremendous potential to improve patient care, there
remain significant challenges before it can be realized. Accuracy and completeness of data, …

Background: Resistant hypertension, or failure to attain blood pressure (BP) goals while
treated with ≥3 antihypertensives (including a diuretic), occurred in 15% to 18% of patients in …

Background There are effective treatments to prevent osteoporotic fractures, but these
treatments are underutilized. Objective To evaluate the influence of patient characteristics, …