Objective Connective tissue growth factor (CTGF; CCN2) is overexpressed in systemic
sclerosis (SSc) and has been hypothesized to be a key mediator of the pulmonary fibrosis …

Objective To determine the potential clinical and pathological significance of altered expression
of interleukin 6 (IL-6) in systemic sclerosis (SSc). Methods Serum IL-6 and soluble IL-6 …

Rationale: Fibrotic response to lung injury depends on development of a fibrogenic
population of myofibroblasts. The importance of resident interstitial fibroblasts and role of …

Aim: The safety and potential efficacy of a chimaeric anti-tumour necrosis factor alpha
monoclonal antibody (infliximab) were examined in diffuse cutaneous systemic sclerosis (dcSSc). …

Previous attempts to delete type II TGFβ receptor (TβRII) in fibroblasts have precluded
examination of adult mice due to early mortality. We have selectively deleted TβRII postnatally in …

Objective. Fibrotic diseases such as SSc (systemic sclerosis, scleroderma) are characterized
by the abnormal presence of the myofibroblast, a specialized type of fibroblast that …

Objective To delineate the constitutive pulmonary vascular phenotype of the TβRIIΔk‐fib
mouse model of scleroderma, and to selectively induce pulmonary endothelial cell injury using …

Objective The excessive deposition of extracellular matrix, including type I collagen, is a key
aspect in the pathogenesis of connective tissue diseases such as systemic sclerosis (SSc; …

Vascular involvement is frequent in systemic sclerosis, but the role of the lymphatic vasculature
is poorly known. Our aim was to evaluate lymphatic vessels in systemic sclerosis skin …

Objective. Gastrointestinal involvement occurs in up to 90% of patients with SSc. Animal models
of SSc mimic some of the pathophysiological disease processes of SSc. The transgenic (…