Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells

T Hirano, M Gotoh, K Oka - Life sciences, 1994 - Elsevier
Anti leukemic-cell efficacy of 28 naturally occurring and synthetic flavonoids and 11 naturally
occurring lignans on human promyelocytic leukemic cell line HL-60 were examined using …

Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs

…, A Kameyama, Y Sashida, T Hirano, K Oka… - Bioorganic & Medicinal …, 1997 - Elsevier
Five cholestane glycosides (1 – 5) including three new ones (3 – 5) with potent cytostatic
activity on leukemia HL-60 cells were isolated from Ornithogalum saundersiae bulbs. …

Effects of Stinging Nettle Root Extracts and Their Steroidal Components on the Na+, K+-ATPase of the Benign Prostatic Hyperplasia1

T Hirano, M Homma, K Oka - Planta medica, 1994 - thieme-connect.com
The effects of organic-solvent extracts of Urtica dioica (Urticaceae) on the Na+, K+-ATPase
of the tissue of benign prostatic hyperplasia (BPH) were investigated. The membrane Na+, K+…

Structural and conformational studies of [Ile7] and [Leu7] surfactins from Bacillus subtilis natto

…, K TAKEYA, T HIRANO, M HOMMA, K OKA - Chemical and …, 1994 - jstage.jst.go.jp
A novel [Ile 7] surfactin (1), which showed anti-human immunodeficiency virus activity, has
been isolated from Bacillus subtilis natto. Structural and conformational analysis of the …

A strategy for discovering biologically active compounds with high probability in traditional Chinese herb remedies: an application of saiboku-to in bronchial asthma

M Homma, K Oka, T Yamada, T Niitsuma, H Ihto… - Analytical …, 1992 - Elsevier
A novel strategy for discovering biologically active components in traditional Chinese herb
remedies was performed from a pharmacokinetic view. The hypothesis was that the active …

Characterization of Tea Cultivated at Four Different Altitudes Using 1H NMR Analysis Coupled with Multivariate Statistics

A Ohno, K Oka, C Sakuma, H Okuda… - Journal of agricultural …, 2011 - ACS Publications
The taste of black tea differs according to the different areas in which the tea is grown, even
for the same species of tea. A combination of 1 H NMR spectroscopy and partial least-…

Clinical significance of glucocorticoid pharmacodynamics assessed by antilymphocyte action in kidney transplantation: marked difference between prednisolone and …

T Hirano, K Oka, H Takeuchi, E Sakurai… - …, 1994 - journals.lww.com
A number of studies have demonstrated the impact of glucocorticoid response of peripheral
lymphocytes on kidney allograft survival, suggesting that the better the glucocorticoid …

Novel cholestane glycosides from the bulbs of Ornithogalum saundersiae and their cytostatic activity on leukemia HL-60 and MOLT-4 cells

M Kuroda, Y Mimaki, Y Sashida, T Hirano, K Oka… - Tetrahedron, 1997 - Elsevier
Two novel 24(23→22)abeo-cholestane glycosides with a six-membered hemiacetal ring
system and a five-membered acetal ring system (2, 3), designated as saundersioside A and B, …

Inhibitory effects of lignans and flavonoids in saiboku-to, a herbal medicine for bronchial asthma, on the release of leukotrienes from human polymorphonuclear …

M Homma, M Minami, C Taniguchi, K Oka… - Planta …, 2000 - thieme-connect.com
To identify the anti-allergic components contained in Saiboku-To, a herbal medicine for the
treatment of bronchial asthma, we studied the effects of eight phenolic compounds, which …

A new immunosuppressive cyclic nonapeptide, cyclolinopeptide B from Linum usitatissimum

…, K Takeya, H Itokawa, T Hirano, K Oka - Bioorganic & Medicinal …, 1997 - Elsevier
A new cyclic nonapeptide, cyclolinopeptide B: cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-),
has been isolated from the seeds of Linum usitatissimum and its structure was elucidated …