Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells

…, HW Lim, QQ Huang, Y Kang, KH Pyun, K Hirasawa… - Science, 1999 - science.org
Glutamic acid decarboxylase (GAD) is a pancreatic β cell autoantigen in humans and
nonobese diabetic (NOD) mice. β Cell–specific suppression of GAD expression in two lines of …

Oncolytic reovirus against ovarian and colon cancer

K Hirasawa, SG Nishikawa, KL Norman, T Alain… - Cancer research, 2002 - AACR
Reovirus selectively replicates in and destroys cancer cells with an activatedRas signaling
pathway. In this study, we evaluated the feasibility of using reovirus (serotype 3, strain Dearing…

Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway

SM Battcock, TW Collier, D Zu, K Hirasawa - Journal of virology, 2006 - Am Soc Microbiol
Interferon (IFN) is one of the molecules released by virus-infected cells, resulting in the
establishment of an antiviral state within infected and neighboring cells. IFN-induced antiviral …

Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection

KL Norman, K Hirasawa, AD Yang… - Proceedings of the …, 2004 - National Acad Sciences
Reovirus is a benign human virus that was recently found to have oncolytic properties and
is currently in clinical trials as a potential cancer therapy. We have previously demonstrated …

Reovirus oncolysis of human breast cancer

KL Norman, MC Coffey, K Hirasawa… - Human gene …, 2002 - liebertpub.com
We have previously shown that human reovirus replication is restricted to cells with an
activated Ras pathway, and that reovirus could be used as an effective oncolytic agent against …

Systemic reovirus therapy of metastatic cancer in immune-competent mice

K Hirasawa, SG Nishikawa, KL Norman, MC Coffey… - Cancer research, 2003 - AACR
The human reovirus is an oncolytic virus that specifically targets cancer cells with an activated
Ras pathway. Because it is replication competent and highly specific for cancer cells, this …

Reovirus therapy of lymphoid malignancies

T Alain, K Hirasawa, KJ Pon… - Blood, The Journal …, 2002 - ashpublications.org
Reoviruses infect cells that manifest an activated Ras-signaling pathway, and have been
shown to effectively destroy many different types of neoplastic cells, including those derived …

Oncolytic viral therapy for prostate cancer: efficacy of reovirus as a biological therapeutic

CM Thirukkumaran, MJ Nodwell, K Hirasawa, ZQ Shi… - Cancer research, 2010 - AACR
Reovirus is a nonattenuated double-stranded RNA virus that exploits aberrant signaling
pathways allowing selective cytotoxicity against multiple cancer histologies. The use of reovirus …

Prognostic value of left ventricular global longitudinal strain in patients with secondary mitral regurgitation

F Namazi, P van der Bijl, K Hirasawa… - Journal of the American …, 2020 - jacc.org
Background Left ventricular (LV) systolic function may be overestimated in patients with
secondary mitral regurgitation (MR) when using LV ejection fraction (EF). LV global longitudinal …

[HTML][HTML] Activation of ERα signaling differentially modulates IFN-γ induced HLA-class II expression in breast cancer cells

AA Mostafa, D Codner, K Hirasawa, Y Komatsu… - PLoS one, 2014 - journals.plos.org
The coordinate regulation of HLA class II (HLA-II) is controlled by the class II transactivator,
CIITA, and is crucial for the development of anti-tumor immunity. HLA-II in breast carcinoma is …