User profiles for Kenichiro Hata
Kenichiro HataVerified email at ncchd.go.jp Cited by 16771 |
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
Imprinted genes are epigenetically marked during gametogenesis so that they are
exclusively expressed from either the paternal or the maternal allele in offspring 1 . Imprinting …
exclusively expressed from either the paternal or the maternal allele in offspring 1 . Imprinting …
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
K Hata, M Okano, H Lei, E Li - 2002 - journals.biologists.com
Genomic imprinting is regulated by differential methylation of the paternal and maternal
genome. However, it remains unknown how parental imprinting is established during …
genome. However, it remains unknown how parental imprinting is established during …
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
…, K Kojima, Y Yamaguchi, TW Ijiri, K Hata… - Genes & …, 2008 - genesdev.cshlp.org
Silencing of transposable elements occurs during fetal gametogenesis in males via de novo
DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse …
DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse …
Dynamic CpG island methylation landscape in oocytes and preimplantation embryos
Elucidating how and to what extent CpG islands (CGIs) are methylated in germ cells is
essential to understand genomic imprinting and epigenetic reprogramming 1 , 2 , 3 . Here we …
essential to understand genomic imprinting and epigenetic reprogramming 1 , 2 , 3 . Here we …
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
DNA methylation is an important epigenetic modification regulating various biological
phenomena, including genomic imprinting and transposon silencing. It is known that methylation …
phenomena, including genomic imprinting and transposon silencing. It is known that methylation …
[HTML][HTML] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks
…, O Yayoi, S Sato, K Nakabayashi, K Hata… - PLoS …, 2012 - journals.plos.org
Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution DNA …
development and genomic imprinting in mammals. Here, we report single-base resolution DNA …
Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions
Despite the importance of DNA methylation in health and disease, technologies to readily
manipulate methylation of specific sequences for functional analysis and therapeutic purposes …
manipulate methylation of specific sequences for functional analysis and therapeutic purposes …
DNA methylation contributes to natural human variation
DNA methylation patterns are important for establishing cell, tissue, and organism phenotypes,
but little is known about their contribution to natural human variation. To determine their …
but little is known about their contribution to natural human variation. To determine their …
[PDF][PDF] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline
Host-defense mechanisms against transposable elements are critical to protect the genome
information. Here we show that tudor-domain containing 9 (Tdrd9) is essential for silencing …
information. Here we show that tudor-domain containing 9 (Tdrd9) is essential for silencing …
[HTML][HTML] Human genetic variation database, a reference database of genetic variations in the Japanese population
Whole-genome and-exome resequencing using next-generation sequencers is a powerful
approach for identifying genomic variations that are associated with diseases. However, …
approach for identifying genomic variations that are associated with diseases. However, …