Imprinted genes are epigenetically marked during gametogenesis so that they are
exclusively expressed from either the paternal or the maternal allele in offspring 1 . Imprinting …

Genomic imprinting is regulated by differential methylation of the paternal and maternal
genome. However, it remains unknown how parental imprinting is established during …

Silencing of transposable elements occurs during fetal gametogenesis in males via de novo
DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse …

Elucidating how and to what extent CpG islands (CGIs) are methylated in germ cells is
essential to understand genomic imprinting and epigenetic reprogramming 1 , 2 , 3 . Here we …

DNA methylation is an important epigenetic modification regulating various biological
phenomena, including genomic imprinting and transposon silencing. It is known that methylation …

Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution DNA …

Despite the importance of DNA methylation in health and disease, technologies to readily
manipulate methylation of specific sequences for functional analysis and therapeutic purposes …

DNA methylation patterns are important for establishing cell, tissue, and organism phenotypes,
but little is known about their contribution to natural human variation. To determine their …

Host-defense mechanisms against transposable elements are critical to protect the genome
information. Here we show that tudor-domain containing 9 (Tdrd9) is essential for silencing …

Whole-genome and-exome resequencing using next-generation sequencers is a powerful
approach for identifying genomic variations that are associated with diseases. However, …