In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise
to generate mutations in virtually every protein-coding gene of the mouse genome in a …

We have developed a new expression vector which allows efficient selection for transfectants
that express foreign genes at high levels. The vector is composed of a ubiquitously strong …

Two cell lines have been established from insulinomas obtained by targeted expression of
the simian virus 40 T antigen gene in transgenic mice. These cell lines, designated MIN6 and …

Interleukin 6 (IL-6) has been suggested to be involved in the pathogenesis of polyclonal and
monoclonal plasma cell abnormalities. To address this possibility, transgenic mice carrying …

We examined the promoter activity of the 1.3-kb chicken β-actin gene sequence located
between the 5' flanking region and the proximal region of the second exon. This promoter region …

We present here an analysis of cardiovascular and pharyngeal arch development in mouse
embryos hypomorphic for Fgf8. Previously, we have described the generation of Fgf8 …

The hallmark of type 2 diabetes, the most common metabolic disorder, is a defect in insulin–stimulated
glucose transport in peripheral tissues. Although a role for phosphoinositide–3–…

Despite the high prevalence of intervertebral disc disease, little is known about changes in
intervertebral disc cells and their regenerative potential with ageing and intervertebral disc …

A mouse model of Rubinstein—Taybi syndrome (RTS) was generated by an insertional
mutation into the cyclic AMP response element-binding protein (CREB)-binding protein (CBP) …

In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia.
Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is …