Oxidative stress refers to elevated reactive oxygen species (ROS) levels, and NADPH
oxidases (NOXs), which are one of the most important sources of ROS. Oxidative stress plays …

UV-sensitive syndrome (UV S S) is a genodermatosis characterized by cutaneous
photosensitivity without skin carcinoma 1 , 2 , 3 , 4 . Despite mild clinical features, cells from …

Osteoclast differentiation is critically dependent on calcium (Ca 2+ ) signaling. Transient
receptor potential vanilloid 4 (TRPV4), mediates Ca 2+ influx in the late stage of osteoclast …

BACKGROUND Analysis of circulating immune complexes (CICs) produced during an
immune response may be useful in elucidating some aspects of this process. Identification of …

In order to evaluate the chemiluminescence (CL) reagents for selective detection of reactive
oxygen species (ROS), we comprehensively measured the CL responses of 20 CL reagents …

A highly sensitive and selective high-performance liquid chromatography (HPLC) method
was developed for the determination of doxorubicin (DXR) and its metabolite doxorubicinol (…

Objective Immune complexes (ICs) trigger humoral immune responses. Therefore, the
identification of constituent antigens within ICs would have very different clinical significance than …

Background Nonhomologous end-joining (NHEJ) is the major DNA double-strand break (DSB)
repair mechanism in human cells. The final rejoining step requires DNA ligase IV (LIG4) …

Quinones are ubiquitous compounds that have two-sided nature; a beneficial one, especially
in the electron transport chain, and a toxic one through the generation of reactive oxygen …

Signaling by extracellular signal–regulated kinase (ERK) plays an essential role in the
induction of cell motility, but the precise mechanism underlying such regulation has remained …