Regulatory T cells (Treg cells) play critical roles in the induction of peripheral tolerance to
self- and foreign antigens. Naturally occurring CD4 + CD25 + Treg cells, which …

Genetic studies have revealed many variant loci that are associated with immune-mediated
diseases. To elucidate the disease pathogenesis, it is essential to understand the function of …

Regulatory T cells (Tregs) participate in the maintenance of tolerance to self-antigens and
suppressive control of excessive immune responses to exogenous antigens. A lack or …

Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is
clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and …

Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic
properties that can enhance or limit immune responses. IL-27 acts on various cell types, …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry
genetic research of RA promises to improve power to detect genetic signals, fine-…

Regulatory T cells (Tregs) are engaged in the maintenance of immunological self-tolerance
and immune homeostasis. IL-10 has an important role in maintaining the normal immune …

IL-17A is a T cell-derived proinflammatory cytokine that contributes to the pathogenesis of
rheumatoid arthritis. Recently, six related molecules have been identified to form the IL-17 …

Rheumatoid arthritis (RA)-associated IgG antibodies such as anti-citrullinated protein antibodies
(ACPAs) have diverse glycosylation variants; however, key sugar chains modulating the …

Recent evidence suggests that a substantial portion of complex disease risk alleles modify
gene expression in a cell-specific manner 1 , 2 , 3 , 4 . To identify candidate causal genes and …