Macrophages phagocytose metallic wear particles and produce mediators, which can induce
cellular host response and aseptic implant loosening. Lipopolysaccharide (LPS) on the …

Tohoku J. Exp. Med., 2004, 204 (2), 99-107── Intra-articular administration of hyaluronate
(HA) is an effective treatment for arthritis. HA injections can decrease not only joint pain but …

Introduction Lag screw cut-out is one of the major postoperative complications on femoral
trochanteric fractures. However, precise analyses of excessive sliding and lag screw cut-out …

Proper mechanical loading is essential for bone remodeling and maintenance of human
skeletal system. Matrix metalloproteinases (MMPs) are secreted by mesenchymal stromal lining …

Objective. Toll-like receptors (TLR) are transmembrane proteins found in various cells. They
recognize infectious and endogenous threats, so-called danger signals, that evoke …

Background: Total hip replacement can be complicated by periprosthetic osteolysis.
Monocytes/macrophages play a major role in the formation of the foreign body granulomas induced …

Toll‐like receptor 2 (TLR2) and nucleotide‐binding and oligomerization domain‐like receptors
with a pyrin domain 3 (NLRP3) inflammasomes have been presumed to participate in the …

Background Although the upper extremity, especially the wrist, has been reported to be the
most commonly injured site in snowboarding, the severity of these injuries is still unknown. …

Purpose Quality-of-life (QOL) assessments in patients with osteonecrosis of the femoral
head (ONFH) have rarely been reported. This multicentre study aimed to elucidate the …

Fatal pulmonary thromboembolism is the most serious complication following surgery.
Patients undergoing major orthopedic surgeries, including total hip replacement, total knee …