Background and objective: Opioid treatment has played a limited role in the management of
diabetic neuropathy, in part because of concerns about the responsiveness of neuropathic …

Linezolid is an oxazolidinone that has activity against most gram-positive bacteria, including
in vitro activity against all Nocardia species and strains. We describe 6 clinical cases of …

Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor
as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of …

Background: Current outpatient management of postoperative pain includes the use of oral
opioid analgesics or nonsteroidal anti-inflammatory drugs; however, both types of …

Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying
drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 (ANGPTL3)…

This multicenter, randomized, double-blind, placebo- and active-controlled trial was conducted
to compare the analgesic efficacy and safety of oxymorphone extended release (ER) with …

Objective. Two studies evaluated efficacy and safety of tanezumab versus naproxen for
treatment of knee or hip osteoarthritis (OA). Methods. Randomized controlled studies [ …

This prospective, 6-week, multicenter, open-label, nonrandomized pilot study was designed
to assess the effectiveness and safety of a lidocaine patch 5% in patients with low back pain …

OBJECTIVE: To evaluate the efficacy and safety of injection of high molecular weight (HMW)
hyaluronan (Orthovisc) in patients with mild, moderate, and severe knee osteoarthritis (OA). …

A buccal film of buprenorphine (BBUP) was evaluated for safety and efficacy in a multicenter,
double-blind, placebo-controlled, enriched-enrollment, randomized-withdrawal study in …