Objective: To determine the effect of two different weekly doses of folic acid on the toxicity
and efficacy of low-dose methotrexate therapy for rheumatoid arthritis. Design: Randomized, …

Thirty‐two patients with rheumatoid arthritis completed a 24‐week, placebo‐controlled,
double‐blind trial of folic acid (FA) supplementation during low‐dose methotrexate (MTX) therapy…

… Other folates and ribotides were synthesized and quantified as previously described (Baggott
& Krumdieck, 1979a,b). Bovine adenosine deaminase (type VIII) and rabbit 5'-adenylic …

Many non-steroidal anti-inflammatory drugs (NSAIDs) (including sulphasalazine, sulindac,
indomethacin, naproxen, salicylic acid, ibuprofen, piroxicam and mefenamic acid) were found …

Background: The anti-folate drug methotrexate (MTX) is commonly used to treat rheumatoid
arthritis. Objective: To determine the allele frequencies of five common coding single-…

Elevated circulating total homocysteine (tHcy) concentrations (hyperhomocysteinemia) have
been regarded as an independent risk factor for cardiovascular disease (CVD). However, …

Several reports suggest that folate has a procarcinogenic effect. Folate has a unique role
because its coenzymes are needed for de novo purine and thymine nucleotide biosynthesis. …

Objective To determine if folinic acid supplementation during methotrexate (MTX) therapy
for rheumatoid arthritis (RA) reduces both urinary 5‐aminoimidazole‐4‐carboxamide (AICA) …

Purine nucleotide biosynthesis de novo (PNB) requires 2 folate-dependent transformylases—5′-phosphoribosyl-glycinamide
(GAR) and 5′-phosphoribosyl-5-aminoimidazole-4-…

Background: There are metabolic and epidemiologic data consistent with the hypothesis that
folate deficiency increases the likelihood of cancer. Conversely, it is also known that folate …