Se ha descrito un nuevo síndrome inflamatorio multisistémico pediátrico vinculado a SARS-CoV-2.
Este cuadro presenta una expresividad clínica variable y se asocia a infección activa …

MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1
receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of …

Assembly of the NLRP3 inflammasome activates caspase-1 and mediates the processing
and release of the leaderless cytokine IL-1β and thereby serves a central role in the …

La enfermedad de Kawasaki (EK) es una vasculitis sistémica, aguda y autolimitada, con
complicaciones potencialmente peligrosas, que afecta principalmente a lactantes y niños …

Background Different diagnostic and classification criteria are available for hereditary
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor-…

Recent therapeutic advances in juvenile idiopathic arthritis (JIA) have made remission an
achievable goal for most patients. Reaching this target leads to improved outcomes. The …

Background Children with osteogenesis imperfecta are often treated with intravenous
bisphosphonates. We aimed to assess the safety and efficacy of risedronate, an orally …

Background In 2012, a European initiative called Single Hub and Access point for pediatric
Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic …

Objective Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and
arthritis, for which interleukin‐1 (IL‐1) and IL‐6 inhibitors appear to be effective treatments. …

Uveitis associated with juvenile idiopathic arthritis (JIA) typically involves the anterior
chamber segment, follows an indolent chronic course, and presents a high rate of uveitic …