Background Methotrexate is the most frequent choice of disease-modifying antirheumatic
therapy for rheumatoid arthritis. Although results of studies have shown the efficacy of such …

Comorbidity is an important confounder in epidemiologic studies. The authors compared
the predictive performance of comorbidity scores for use in epidemiologic research with …

Background Several passive surveillance systems reported increased risks of myocarditis or
pericarditis, or both, after COVID-19 mRNA vaccination, especially in young men. We used …

Background Aprotinin (Trasylol) is used to mitigate bleeding during coronary-artery bypass
grafting (CABG). Accumulating evidence suggests that this practice increases mortality. …

Full article: Use of a claims-based active drug safety surveillance system to assess the risk
of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide Skip to …

Although the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, share
a common lipid-lowering effect, there are differences within this class of drugs. The low-…

OBJECTIVE: The oral contraceptive ethinylestradiol 0.03 mg/drospirenone 3 mg contains a
progestin component that differs from other oral contraceptives. Case reports and …

Background Confounding by indication is a common problem in pharmacoepidemiology,
where predictors of treatment also have prognostic value for the outcome of interest. The tools …

Background: There are few data regarding the utilization of opioids during pregnancy. The
objective of this study was to define the prevalence and patterns of opioid use in a large …

Background . Previous observational studies found highly active antiretroviral therapy (HAART)
to be associated with improved survival among human immunodeficiency virus (HIV)– …