Mature donor T cells cause graft-versus-host disease (GVHD), but they are also the main
mediators of the beneficial graft-versus-tumor (GVT) activity of allogeneic bone marrow …

Acute graft-versus-host disease (aGVHD) is still a major obstacle in clinical allogeneic bone
marrow (BM) transplantation. CD4 + CD25 + regulatory T (T reg ) cells have recently been …

Objective To provide evidence‐based recommendations for the treatment of patients with
ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). Methods A core …

CD4 + CD25 + regulatory T (Treg) cells are potent modulators of alloimmune responses. In
murine models of allogeneic bone marrow transplantation, adoptive transfer of donor CD4 + …

Recently, CD4+ CD25+ T cells have been implicated in the control of diabetes, suggesting
that the inflamed islets of Langerhans in prediabetic NOD mice are under peripheral immune …

Biomarkers are needed to guide treatment decisions for patients with rheumatic diseases.
Although the phenotypic and functional analysis of immune cells is an appealing strategy for …

There is a clinical need for new, more effective treatments for chronic and debilitating
inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis. Targeting …

Axial spondyloarthritis (axSpA) is an important cause of chronic low back pain and affects
approximately 1% of the US population. The back pain associated with axSpA has a …

Recent advances have dramatically increased our understanding of how organ systems
interact. This has been especially true for immunology and bone biology, where the term “…

In this Overview, common themes of the accompanying News & Views on RA, SLE, IDDM,
thyroiditis and MS are discussed. A unifying concept for the development of these and other …