THE intracellular protein tyrosine kinase FAK (focal adhesion kinase) was originally identified
by its high level of tyrosine phosphorylation in v-src-transformed cells 1á¤-4 . FAK is also …

The 2; 5 chromosomal translocation is frequently associated with anaplastic large cell
lymphomas (ALCLs). The translocation creates a fusion gene consisting of the alk (anaplastic …

The 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases play a pivotal role in the
mitogenic signal transduction pathway and are essential components of the MAP kinase …

Liver cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration,
characterized by diffuse disorganization of the normal hepatic structure of regenerative …

Systemic administration of IL-18 induces polyclonal IgE responses by causing NKT cells to
express CD40 ligand and to produce IL-4. Administration of IL-33 also induces IgE response, …

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK)
is a key molecule in intracellular signal transducing pathways that transport extracellular …

The c‐met proto‐oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor
(HGF), a potent mitogen and motogen for epithelial cells. Because of its profound effects …

Eukaryotic proteins are frequently produced in Escherichia coli as insoluble aggregates. This
is one of the barriers to studies of macromolecular structure. We have examined the effect …

IL-18, produced as biologically inactive precursor, is secreted from LPS-stimulated macrophages
after cleavage by caspase-1. In this study, we investigated the mechanism underlying …

We compared liver volume and function kinetics after partial hepatectomy according to
extent of resection and severity of coexisting liver disease in 57 adults with uneventful …