Objective Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis due
to excessive and dysregulated collagen production by fibroblasts. Previously, we reported …

Objective Fibroblasts play a crucial role in the development of systemic sclerosis (SSc), and
antifibroblast antibodies (AFAs) capable of inducing a proinflammatory phenotype in …

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …

Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA.
However, association of host DNA with autoantibodies activates TLR9, inducing the …

Canonically, immunoglobulin E (IgE) mediates allergic immune responses by triggering mast
cells and basophils to release histamine and type 2 helper cytokines. Here we found that in …

Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete
large amounts of type I interferon (IFN) but also serve to enable both innate and adaptive …

… Author links open overlay panel Payal Mehta 1 , Jill Henault 1 , Roland Kolbeck , Miguel
A Sanjuan … Henault, J. Martinez, JM Riggs, J. Tian, P. …

Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders
such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in …

Objective A growing number of intracellular autoantigenic polypeptides have been found to
play a second biologic role when they are present in the extracellular medium. We undertook …

Systemic lupus erythematosus (SLE) impacts multiple organ systems, although the causes
of many individual SLE pathologies are poorly understood. This study was designed to …