Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific …

…, S Thiel, K Varming, C Jersild, JC Jensenius - Journal of …, 2000 - Elsevier
This study describes a new approach to the determination of all known mannan-binding
lectin (MBL) mutations. The distribution of known variants of the MBL gene in a population of …

The mannan-binding lectin pathway of complement activation: biology and disease association

SV Petersen, S Thiel, JC Jensenius - Molecular immunology, 2001 - Elsevier
Mannan-binding lectin (MBL) is a plasma protein found in association with several serine
proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures …

Mannose-binding Lectin-deficient Mice Are Susceptible to Infection with Staphylococcus aureus

…, S Shahroor-Karni, S Thiel, JC Jensenius… - The Journal of …, 2004 - rupress.org
Gram-positive organisms like Staphylococcus aureus are a major cause of morbidity and
mortality worldwide. Humoral response molecules together with phagocytes play a role in host …

Clinical manifestations of mannan-binding lectin deficiency

S Thiel, PD Frederiksen, JC Jensenius - Molecular immunology, 2006 - Elsevier
Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability
to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10…

Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury

…, B Kessler, S Thiel, JC Jensenius… - The journal of …, 2006 - journals.aai.org
Reperfusion of ischemic tissues elicits an acute inflammatory response involving serum
complement, which is activated by circulating natural IgM specific to self-Ags exposed by …

Passage of undegraded dietary antigen into the blood of healthy adults: quantification, estimation of size distribution, and relation of uptake to levels of specific …

S Husby, JC Jensenius… - Scandinavian journal of …, 1985 - Wiley Online Library
The absorption into the blood of ovalbumin (OA) and beta‐lactoglobulin (BLG) was investigated
in eight healthy adults. Enzyme immunoassays showed up to 10.5 ng OA/ml serum in …

Mannan‐binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury

…, L Shi, A Ezekowitz, JC Jensenius… - Scandinavian …, 2005 - Wiley Online Library
Organ damage as a consequence of ischaemia and reperfusion (I/R) is a major clinical
problem in an acute renal failure and transplantation. Ligands on surfaces of endothelial cells …

Control of the classical and the MBL pathway of complement activation

…, L Jensen, T Vorup-Jensen, C Koch, JC Jensenius - Molecular …, 2000 - Elsevier
The activation of complement via the mannan-binding lectin (MBL) pathway is initiated by the
MBL complex consisting of the carbohydrate binding molecule, MBL, two associated serine …

Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms

…, H Eiberg, M Gadjeva, M Ruseva, JC Jensenius - Genes & …, 2007 - nature.com
Mannan-binding lectin (MBL) and ficolins distinguish between self, non-self and altered-self
by recognizing patterns of ligands on the surface of microorganisms or aberrant cells. When …

Lectin complement pathway proteins in healthy individuals

…, A Hansen, SWK Hansen, JC Jensenius… - Clinical & …, 2017 - academic.oup.com
Since the discovery of the lectin pathway of complement activation, numerous clinical
cohorts have been examined for one or more proteins, with the intention of uncovering the …