We compared the antigen-specific antibody isotypes and lymphokine secretion by CD4+ T
cells in BALB/c mice immunized intradermally with either Escherichia coli beta-galactosidase (…

Objective A distinct subset of proinflammatory CD4+ T cells that produce interleukin‐17 was
recently identified. These cells are implicated in different autoimmune disease models, such …

Objective Patients with rheumatoid arthritis (RA) in whom the response to anti–tumor
necrosis factor (anti‐TNF) therapy is inadequate have several therapeutic options, such as …

Objective To evaluate the baseline characteristics of patients with radiographic axial
spondyloarthritis (SpA; ankylosing spondylitis [AS]) and patients with nonradiographic axial SpA, to …

Objectives Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of
symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. …

Background Patients receiving anti-TNF-α therapy for rheumatic or chronic inflammatory bowel
diseases are at higher risk of developing tuberculosis during treatment than patients with …

Plasmid DNA and adenovirus vectors currently used in cardiovascular gene therapy trials are
limited by low efficiency and short-lived transgene expression, respectively. Recombinant …

The value of the study by MacLean and colleagues goes beyond revealing another source
of unpublished trials. First, it is surely deplorable that most of the FDA-sourced randomised …

OBJECTIVE To evaluate the effect of murine interleukin 17 (IL17) on cartilage catabolism
and joint inflammation by direct intra-articular injection of the cytokine into murine knee joints. …

Purpose Spine-related disorders are a leading cause of global disability and are a burden
on society and to public health. Currently, there is no comprehensive, evidence-based model …