Ventilator-associated pneumonia

J Chastre, JY Fagon - American journal of respiratory and critical …, 2002 - atsjournals.org
Ventilator-associated pneumonia (VAP) continues to complicate the course of 8 to 28% of
patients receiving mechanical ventilation (MV). In contrast to infections of more frequently …

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections

…, CE Luyt, M Wolff, J Chastre… - … ‐Based Child Health …, 2013 - Wiley Online Library
Background Acute respiratory infections (ARIs) comprise a large and heterogeneous group
of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin ‐ …

[HTML][HTML] Antibiotic stewardship in the intensive care unit

CE Luyt, N Bréchot, JL Trouillet, J Chastre - Critical care, 2014 - Springer
The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs
worldwide constitute a problem of crisis dimensions. The root causes of this problem are …

Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial

J Chastre, M Wolff, JY Fagon, S Chevret, F Thomas… - Jama, 2003 - jamanetwork.com
ContextThe optimal duration of antimicrobial treatment for ventilator-associated pneumonia (VAP)
is unknown. Shortening the length of treatment may help to contain the emergence of …

Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay

JY Fagon, J Chastre, AJ Hance, P Montravers… - The American journal of …, 1993 - Elsevier
purpose: Although nosocomial pneumonia is a common problem in intubated and ventilated
patients, previous studies have not clearly demonstrated that nosocomial pneumonia …

Nosocomial pneumonia in patients receiving continuous mechanical ventilation: prospective analysis of 52 episodes with use of a protected specimen brush and …

JY Fagon, J Chastre, Y Domart, JL Trouillet… - American Review of …, 1989 - atsjournals.org
Epidemiologic studies of nosocomial bacterial pneumonia in patients requiring mechanical
ventilation have been limited because of the poor reliability of diagnosis procedures in this …

Ventilator-associated pneumonia caused by potentially drug-resistant bacteria

JL Trouillet, J Chastre, A Vuagnat… - American journal of …, 1998 - atsjournals.org
To determine risk factors for ventilator-associated pneumonia (VAP) caused by potentially
drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus, Pseudomonas …

Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial

JY Fagon, J Chastre, M Wolff, C Gervais… - Annals of internal …, 2000 - acpjournals.org
Background: Optimal management of patients who are clinically suspected of having
ventilator-associated pneumonia remains open to debate. Objective: To evaluate the effect on …

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

…, B Pasquet, B Régnier, C Brun-Buisson, J Chastre… - The Lancet, 2010 - thelancet.com
Background Reduced duration of antibiotic treatment might contain the emergence of
multidrug-resistant bacteria in intensive care units. We aimed to establish the effectiveness of an …

International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the …

A Torres, MS Niederman, J Chastre… - European …, 2017 - Eur Respiratory Soc
The most recent European guidelines and task force reports on hospital-acquired pneumonia
(HAP) and ventilator-associated pneumonia (VAP) were published almost 10 years ago. …