User profiles for Jason S. Knight
Jason S. Knight, MD, PhDAssociate Professor, Division of Rheumatology, University of Michigan Verified email at umich.edu Cited by 13588 |
[HTML][HTML] Targeting potential drivers of COVID-19: Neutrophil extracellular traps
…, S Renaud, S Rousseau, S Salvatore… - Journal of Experimental …, 2020 - rupress.org
Disclosures: MR Looney reported" other" from Neutrolis outside the submitted work. RE
Schwartz is a Sponsored Advisory Board Member for Miromatrix Inc. JD Spicer reported …
Schwartz is a Sponsored Advisory Board Member for Miromatrix Inc. JD Spicer reported …
[HTML][HTML] Neutrophil extracellular traps in COVID-19
In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to
respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, …
respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, …
NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis
…, S Yalavarthi, JS Knight, S Friday, S Li… - Science translational …, 2013 - science.org
The early events leading to the development of rheumatoid arthritis (RA) remain unclear,
but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …
but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …
The 2023 ACR/EULAR antiphospholipid syndrome classification criteria
Objective To develop new antiphospholipid syndrome (APS) classification criteria with high
specificity for use in observational studies and trials, jointly supported by the American …
specificity for use in observational studies and trials, jointly supported by the American …
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19
…, SA Smith, JH Morrissey, Y Kanthi, JS Knight - Science translational …, 2020 - science.org
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung
histopathology often reveals fibrin-based blockages in the small blood vessels of patients …
histopathology often reveals fibrin-based blockages in the small blood vessels of patients …
[HTML][HTML] Patients with COVID-19: in the dark-NETs of neutrophils
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it is …
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it is …
[HTML][HTML] Neutrophil extracellular traps and thrombosis in COVID-19
…, W Woodard, SP Lezak, NL Lugogo, JS Knight… - Journal of Thrombosis …, 2021 - Springer
Studies of patients with COVID-19 have demonstrated markedly dysregulated coagulation
and a high risk of morbid arterial and venous thrombotic events. Elevated levels of blood …
and a high risk of morbid arterial and venous thrombotic events. Elevated levels of blood …
Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis
JS Knight, W Luo, AA O'Dell, S Yalavarthi… - Circulation …, 2014 - Am Heart Assoc
Rationale: Neutrophil extracellular trap (NET) formation promotes vascular damage,
thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in diseased …
thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in diseased …
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice
JS Knight, V Subramanian, AA O'Dell… - Annals of the …, 2015 - ard.bmj.com
Objectives An imbalance between neutrophil extracellular trap (NET) formation and degradation
has been described in systemic lupus erythematosus (SLE), potentially contributing to …
has been described in systemic lupus erythematosus (SLE), potentially contributing to …
[HTML][HTML] Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus
Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates
plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose …
plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose …