User profiles for Jason S. Knight

Jason S. Knight, MD, PhD

Associate Professor, Division of Rheumatology, University of Michigan
Verified email at umich.edu
Cited by 13588

[HTML][HTML] Targeting potential drivers of COVID-19: Neutrophil extracellular traps

…, S Renaud, S Rousseau, S Salvatore… - Journal of Experimental …, 2020 - rupress.org
Disclosures: MR Looney reported" other" from Neutrolis outside the submitted work. RE
Schwartz is a Sponsored Advisory Board Member for Miromatrix Inc. JD Spicer reported …

[HTML][HTML] Neutrophil extracellular traps in COVID-19

…, M Egeblad, RJ Woods, Y Kanthi, JS Knight - JCI insight, 2020 - ncbi.nlm.nih.gov
In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to
respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, …

NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis

…, S Yalavarthi, JS Knight, S Friday, S Li… - Science translational …, 2013 - science.org
The early events leading to the development of rheumatoid arthritis (RA) remain unclear,
but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …

The 2023 ACR/EULAR antiphospholipid syndrome classification criteria

…, N Jordan, RK Leaf, N Kello, JS Knight… - Arthritis & …, 2023 - Wiley Online Library
Objective To develop new antiphospholipid syndrome (APS) classification criteria with high
specificity for use in observational studies and trials, jointly supported by the American …

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

…, SA Smith, JH Morrissey, Y Kanthi, JS Knight - Science translational …, 2020 - science.org
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung
histopathology often reveals fibrin-based blockages in the small blood vessels of patients …

[HTML][HTML] Patients with COVID-19: in the dark-NETs of neutrophils

…, B Hohberger, Y Kanthi, MJ Kaplan, JS Knight… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it is …

[HTML][HTML] Neutrophil extracellular traps and thrombosis in COVID-19

…, W Woodard, SP Lezak, NL Lugogo, JS Knight… - Journal of Thrombosis …, 2021 - Springer
Studies of patients with COVID-19 have demonstrated markedly dysregulated coagulation
and a high risk of morbid arterial and venous thrombotic events. Elevated levels of blood …

Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis

JS Knight, W Luo, AA O'Dell, S Yalavarthi… - Circulation …, 2014 - Am Heart Assoc
Rationale: Neutrophil extracellular trap (NET) formation promotes vascular damage,
thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in diseased …

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice

JS Knight, V Subramanian, AA O'Dell… - Annals of the …, 2015 - ard.bmj.com
Objectives An imbalance between neutrophil extracellular trap (NET) formation and degradation
has been described in systemic lupus erythematosus (SLE), potentially contributing to …

[HTML][HTML] Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

JS Knight, W Zhao, W Luo… - The Journal of …, 2013 - Am Soc Clin Investig
Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates
plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose …