[PDF][PDF] Familial primary pulmonary hypertension (Gene PPH1) is caused by mutations in the bone morphogenetic protein receptor–II gene

Z Deng, JH Morse, SL Slager, N Cuervo… - The American Journal of …, 2000 - cell.com
Familial primary pulmonary hypertension is a rare autosomal dominant disorder that has
reduced penetrance and that has been mapped to a 3-cM region on chromosome 2q33 (locus …

Prognostic factors for survival in human immunodeficiency virus–associated pulmonary arterial hypertension

H Nunes, M Humbert, O Sitbon, JH Morse… - American journal of …, 2003 - atsjournals.org
We report a large monocentric case series of 82 patients with human immunodeficiency
virus–associated pulmonary arterial hypertension (PAH). No germline mutations of the PPH1 …

Genetic basis of pulmonary arterial hypertension: current understanding and future directions

JH Newman, RC Trembath, JA Morse, E Grunig… - Journal of the American …, 2004 - jacc.org
Mutations in two receptors of the transforming growth factor-beta family have recently been
shown to be present in the majority of cases of inherited (familial) pulmonary arterial …

Clinical implications of determining BMPR2 mutation status in a large cohort of children and adults with pulmonary arterial hypertension

EB Rosenzweig, JH Morse, JA Knowles… - The Journal of heart and …, 2008 - Elsevier
BACKGROUND: Bone morphogenetic protein receptor type 2 (BMPR2) mutations occur in
idiopathic and familial pulmonary arterial hypertension (IPAH, FPAH); however, the impact of …

Mapping of Familial Primary Pulmonary Hypertension Locus (PPH1) to Chromosome 2q31-q32

JH Morse, AC Jones, RJ Barst, SE Hodge… - Circulation, 1997 - Am Heart Assoc
Background The pathogenesis of primary pulmonary hypertension (PPH) is unknown,
although in some instances families with multiple affected members suggest a genetic etiology. …

Fine Mapping of PPH1, a Gene for Familial Primary Pulmonary Hypertension, to a 3-cM Region on Chromosome 2q33

…, EM Horn, RJ Barst, SE Hodge, JH Morse… - American journal of …, 2000 - atsjournals.org
Familial primary pulmonary hypertension (PPH) is a rare autosomal dominant disease
characterized by distinctive changes in pulmonary arterioles that lead to increased pulmonary …

Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension

WKP Wong, JA Knowles, JH Morse - American journal of respiratory …, 2005 - atsjournals.org
Mutations of bone morphogenetic protein receptor type II (BMPR-II) have been associated
with familial and idiopathic pulmonary arterial hypertension (PAH). BMPR-II is a member of …

Primary pulmonary hypertension in HIV infection: an outcome determined by particular HLA class II alleles.

JH Morse, RJ Barst, S Itescu, ER Flaster… - American journal of …, 1996 - atsjournals.org
Primary pulmonary hypertension (PPH) may have an autoimmune basis that is influenced
by host immunogenetics. The pathogenesis of primary pulmonary hypertension in human …

Hormone replacement therapy: a possible risk factor in carriers of familial primary pulmonary hypertension

JH Morse, EM Horn, RJ Barst - Chest, 1999 - journal.chestnet.org
2 Irey N, Norris H. Intimal vascular lesions associated with female reproductive steroids.
Arch Pathol 1973; 96: 227–234 3 Morse JH, Jones AC, Barst RJ, et al. Mapping of familial …

Pulmonary hypertension in scleroderma spectrum of disease: lack of bone morphogenetic protein receptor 2 mutations.

J Morse, R Barst, E Horn, N Cuervo, Z Deng… - The Journal of …, 2002 - jrheum.org
OBJECTIVE: To determine whether mutations in the bone morphogenetic protein receptor 2
gene (BMPR2), initially reported in primary pulmonary hypertension, were present in …