Background Neuraminidase inhibitors were widely used during the 2009–10 influenza A H1N1
pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a …

Background Tens of millions of children are exposed to Mycobacterium tuberculosis
globally every year; however, there are no contemporary estimates of the risk of developing …

Background BCG vaccines are given to more than 100 million children every year, but there
is considerable debate regarding the effectiveness of BCG vaccination in preventing …

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …

Background The post-2015 End TB Strategy proposes targets of 50% reduction in tuberculosis
incidence and 75% reduction in mortality from tuberculosis by 2025. We aimed to assess …

We present a mathematical model to simulate tuberculosis (TB) transmission in highly endemic
regions of the Asia-Pacific, where epidemiology does not appear to be primarily driven …

Preexisting T-cell immunity directed at conserved viral regions promotes enhanced recovery
from influenza virus infections, with there being some evidence of cross-protection directed …

Background Convalescent plasma has been widely used to treat COVID-19 and is under
investigation in numerous randomized clinical trials, but results are publicly available only for a …

Adolescence is characterised by a substantial increase in the incidence of tuberculosis, a
known fact since the early 20th century. Most of the world's adolescents live in low-income and …

Importance Practice guidelines often provide recommendations in which the strength of the
recommendation is dissociated from the quality of the evidence. Objective To create a clinical …