User profiles for JOSEPH KEANE

Joseph Keane

Trinity College Dublin
Verified email at stjames.ie
Cited by 17813

[HTML][HTML] Tuberculosis associated with infliximab, a tumor necrosis factor α–neutralizing agent

J Keane, S Gershon, RP Wise… - … England Journal of …, 2001 - Mass Medical Soc
Background Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that
is used in the treatment of Crohn's disease and rheumatoid arthritis. Approximately 147,000 …

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention clinical practice guidelines: diagnosis of …

…, CL Daley, E Desmond, J Keane… - Clinical Infectious …, 2017 - academic.oup.com
Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms
and signs of disease (tuberculosis disease) or may have no clinical evidence of disease …

[PDF][PDF] Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

…, DGW Johnston, J Jiang, WJ Israelsen, J Keane… - Cell metabolism, 2015 - cell.com
Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their
metabolic activity. We here show that LPS induces expression of the key metabolic regulator …

The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study

…, M Jankovic, E Jong, J Keane… - European …, 2013 - Eur Respiratory Soc
A significant knowledge gap exists concerning the geographical distribution of nontuberculous
mycobacteria (NTM) isolation worldwide. To provide a snapshot of NTM species …

Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages

J Keane, HG Remold, H Kornfeld - The Journal of Immunology, 2000 - journals.aai.org
Human alveolar macrophages (AMφ) undergo apoptosis following infection with Mycobacterium
tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit …

Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis

J Keane, MK Balcewicz-Sablinska… - Infection and …, 1997 - Am Soc Microbiol
The effect of Mycobacterium tuberculosis infection on the viability of healthy (control) human
alveolar macrophages was evaluated by staining with ethidium homodimer and calcein to …

Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

…, J Beamis, C Lamb, T Anderson, N Gerry, J Keane… - Nature medicine, 2007 - nature.com
Lung cancer is the leading cause of death from cancer in the US and the world 1 . The high
mortality rate (80–85% within 5 years) results, in part, from a lack of effective tools to …

[HTML][HTML] T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis

J Harris, SA De Haro, SS Master, J Keane, EA Roberts… - Immunity, 2007 - cell.com
Autophagy is a recently recognized immune effector mechanism against intracellular pathogens.
The role of autophagy in innate immunity has been well established, but the extent of its …

Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-α

MK Balcewicz-Sablinska, J Keane… - The journal of …, 1998 - journals.aai.org
Infection by Mycobacterium tuberculosis (MTB) induces human alveolar macrophage (AMφ)
apoptosis by a TNF-α-dependent mechanism. The apoptotic response is postulated to be a …

How tumour necrosis factor blockers interfere with tuberculosis immunity

J Harris, J Keane - Clinical & Experimental Immunology, 2010 - academic.oup.com
Tumour necrosis factor (TNF) is a potent inflammatory cytokine that plays an important role in
immunity to numerous bacterial infections, including Mycobacterium tuberculosis (Mtb), the …