Accumulation of myeloid-derived suppressor cells (MDSCs) associated with inhibition of
dendritic cell (DC) differentiation is one of the major immunological abnormalities in cancer and …

The role of the pore-forming Staphylococcus aureus toxin Panton-Valentine leukocidin (PVL)
in severe necrotizing diseases is debated due to conflicting data from epidemiological …

Tumor recurrence years after seemingly successful treatment of primary tumors is one of the
major causes of mortality in patients with cancer. Reactivation of dormant tumor cells is …

To identify new components that regulate the inflammatory cascade during sepsis, we
characterized the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related …

Damage-associated molecular pattern (DAMP) molecules have been introduced as important
proinflammatory factors of innate immunity. One example known for many years to be …

S100A8 and S100A9 are novel members of the group of damage–associated molecular
pattern molecules (DAMP) which are early amplifiers of innate immune responses to tissue …

Myeloid-related protein (MRP) 8 and MRP14, two members of the S100 family expressed in
myelomonocytic cells, have been ascribed some extracellular functions, eg antimicrobial, …

Allergies to nickel (Ni 2+ ) are the most frequent cause of contact hypersensitivity (CHS) in
industrialized countries. The efficient development of CHS requires both a T lymphocyte-…

Alarmins are endogenous molecules that are constitutively available and released upon
tissue damage and activate the immune system. Current evidence indicates that uncontrolled …

Three members of the S100 family of calcium-binding proteins comprise a new group of
proinflammatory molecules released by phagocytes. A novel inflammatory syndrome defined by …