In recent years quality of life instruments have been featured as primary outcomes in many
randomized trials. One of the challenges facing the investigator using such measures is …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by
features reminiscent of marked premature ageing 1 , 2 . Here, we present evidence of …

Background Vasopressin is commonly used as an adjunct to catecholamines to support blood
pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized …

A randomized controlled trial with 76 physicians in 16 community hospitals evaluated audit
and feedback and local opinion leader education as methods of encouraging compliance …

We have developed a measure of subjective health status (quality of life) for patients with
inflammatory bowel disease (IBD). Ninety-seven patients with IBD described problems they …

We performed a randomized, double-blind, placebo-controlled trial in 555 patients with
unstable angina who were hospitalized in coronary care units. Patients received one of four …

Cardiovascular disease occurs in patients with progressive renal disease both before and
after the initiation of dialysis. Left ventricular hypertrophy (LVH) is an independent predictor of …

Left ventricular hypertrophy (LVH) is present in over 70% of patients commencing dialysis. It
is an independent risk factor for cardiac death, which is the cause of death in approximately …

Background The effects of less-tight versus tight control of hypertension on pregnancy
complications are unclear. Methods We performed an open, international, multicenter trial …

Background Febrile, nonhemolytic transfusion reactions are the most frequent adverse
reactions to platelets. A number of observations argue against the widely held view that these …