Prevalence and metric of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis

…, M Kravtsenyuk, W Fung, L Eder, J Su, JE Wither… - Seminars in arthritis and …, 2020 - Elsevier
Objectives To systematically review and synthesize literature on 1) the overall prevalence of
depression and anxiety in SLE patients in identified studies, and 2) the pooled prevalence …

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

…, AC Syvänen, L Rönnblom, RR Graham, JE Wither… - Nature …, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized
by loss of immune tolerance to nuclear and cell surface antigens. Previous genome-…

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

…, C Gates, RM Plenge, TW Behrens, JE Wither… - Nature …, 2008 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and
environmental factors. We carried out a genome-wide association scan and replication study …

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

…, A Cohen, D Langelier, PR Fortin, JE Wither… - Nature …, 2009 - nature.com
We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory
region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and …

[HTML][HTML] Transancestral mapping and genetic load in systemic lupus erythematosus

…, LM Vilá, DJ Wallace, MH Weisman, JE Wither… - Nature …, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using Immunochip …

Metrics and definitions used in the assessment of cognitive impairment in systemic lupus erythematosus: a systematic review

…, M Zandy, MY Choi, MJ Fritzler, JE Wither… - Seminars in arthritis and …, 2021 - Elsevier
Objective To review: 1) degree of conformity to the American College of Rheumatology
neuropsychological battery (ACR-NB) among studies that used a NB, 2) review definitions of …

Association of systemic lupus erythematosus (SLE) genetic susceptibility loci with lupus nephritis in childhood-onset and adult-onset SLE

…, AD Paterson, Z Touma, MB Urowitz, JE Wither… - …, 2020 - academic.oup.com
Objective LN is one of the most common and severe manifestations of SLE. Our aim was to
test the association of SLE risk loci with LN risk in childhood-onset SLE (cSLE) and adult-…

[HTML][HTML] Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical …

JE Wither, SD Prokopec, B Noamani, NH Chang… - PloS one, 2018 - journals.plos.org
Both a lack of biomarkers and relatively ineffective treatments constitute impediments to
management of lupus nephritis (LN). Here we used gene expression microarrays to contrast the …

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins

…, JC Zuniga-Pflucker, KW Rosbe, JE Wither… - Journal of …, 2018 - Elsevier
Genome editing in human cells with targeted nucleases now enables diverse experimental
and therapeutic genome engineering applications, but extension to primary human B cells …

Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus

…, D Gladman, M Urowitz, JE Wither - The Journal of …, 2008 - journals.aai.org
Polyclonal B cell activation is a well-described feature of systemic lupus erythematosus (SLE),
but the immune mechanisms leading to this activation are unclear. To gain insight into …