Rheumatoid arthritis (RA) is a heterogeneous syndrome of which a subset of patients develops
vascular inflammation. The genetic determinants that confer risk for rheumatoid vasculitis …

Objective To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify
Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by …

Objective. The expression of autoimmunity in mice deficient in programmed death 1 (PD‐1)
suggests that PD‐1 is a candidate gene involved in the development of human autoimmune …

Expansion of CD4+ CD28 null T cells is a characteristic finding in patients with rheumatoid
arthritis. Despite lacking CD28 molecules, these unusual CD4 T cells undergo clonal …

The role of naturally occurring regulatory T cells (Treg), known to be phenotypically heterogeneous,
in controlling the expression of systemic lupus erythematosus (SLE) is incompletely …

OBJECTIVES: To investigate the associations of DNA methylation levels and mRNA expressions
of DNA cytosine-5-methyltransferase 1 (DNMT1) and methyl CpG-binding domain 2 (…

The objective of this case-control study was to investigate the risk of cardiovascular disease
(CVD) following non-steroidal anti-inflammatory drug (NSAID) use in patients with …

Although many genome-wide association studies (GWASs) of hyperuricemia or gout have
been reported, the related genetic factors and the mechanisms from hyperuricemia to gouty …

Platelet activation and aggregation underlie acute thrombosis that leads to ST-elevation
myocardial infarction (STEMI). L5—highly electronegative low-density lipoprotein (LDL)—is …

Stroke is one of the leading causes of death in the world. Most stroke patients are classified
as having ischemic stroke. The causes of ischemic stroke are very diverse. Atherosclerosis …