Multiple covalent modifications exist in the amino-terminal tails of core histones, but whether
a relationship exists between them is unknown. We examined the relationship between …

Gene activation is a highly regulated process that requires the coordinated action of proteins
to relieve chromatin repression and to promote transcriptional activation. Nuclear histone …

The yeast GCN5 (yGCN5) transcriptional coactivator functions as a histone acetyltransferase
(HAT) to promote transcriptional activation. Here, we present the high resolution crystal …

Infliximab (IFX) is a chimeric IgG1 monoclonal antibody specific for human tumor necrosis
factor-α that is approved in the United States and Europe for the treatment of rheumatoid …

The human p 300/C BP‐a ssociating f actor, PCAF, mediates transcriptional activation through
its ability to acetylate nucleosomal histone substrates as well as transcriptional activators …

Objective: To incorporate a new trial design to examine clinical response, cytokine expression
and joint imaging in patients with rheumatoid arthritis (RA) switching from etanercept to …

Objective. To assess the effect of golimumab (human monoclonal antibody to tumor necrosis
factor-α) plus methotrexate (MTX) on selected inflammatory biomarkers, and to determine if …

Gal4 is the prototypical Zn 2 Cys 6 binuclear cluster transcriptional regulator that binds as a
homodimer to DNA containing inverted CGG half-sites. Leu3, a member of this protein family, …

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Purpose: Infliximab (IFX) is a chimeric IgG1 antibody approved for the treatment of rheumatoid
arthritis and Crohn's disease (CD). A small percentage of patients receiving IFX develop …