[HTML][HTML] Selective regulation of Gαq/11 by an RGS domain in the G protein-coupled receptor kinase, GRK2
G protein-coupled receptor kinases (GRKs) are well characterized regulators of G protein-coupled
receptors, whereas regulators of G protein signaling (RGS) proteins directly control …
receptors, whereas regulators of G protein signaling (RGS) proteins directly control …
[HTML][HTML] Trafficking of the HIV coreceptor CXCR4: role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization
MJ Orsini, JL Parent, SJ Mundell, JL Benovic - Journal of Biological …, 1999 - ASBMB
The G protein-coupled chemokine receptor CXCR4 serves as the primary coreceptor for entry
of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic internalization as …
of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic internalization as …
Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression
…, K Halder, A Verma, A Kar, JL Parent… - Nucleic acids …, 2009 - academic.oup.com
Regulatory influence of the G-quadruplex or G4 motif present within the nuclease
hypersensitive element (NHE) in the promoter of c-MYC has been noted. On the other hand, …
hypersensitive element (NHE) in the promoter of c-MYC has been noted. On the other hand, …
[HTML][HTML] Internalization of the TXA2 receptor α and β isoforms: Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization
JL Parent, P Labrecque, MJ Orsini… - Journal of Biological …, 1999 - ASBMB
Thromboxane A 2 (TXA 2 ) potently stimulates platelet aggregation and smooth muscle
constriction and is thought to play a role in myocardial infarction, atherosclerosis, and bronchial …
constriction and is thought to play a role in myocardial infarction, atherosclerosis, and bronchial …
[HTML][HTML] Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50)
…, A Bisello, CE Magyar, MD Rochdi, JL Parent… - Journal of Biological …, 2003 - ASBMB
Parathyroid hormone (PTH) regulates extracellular calcium homeostasis through the type 1
PTH receptor (PTH1R) expressed in kidney and bone. The PTH1R undergoes β-arrestin/…
PTH receptor (PTH1R) expressed in kidney and bone. The PTH1R undergoes β-arrestin/…
Pharmacological inhibition of protein kinases in intact cells: antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness
RB Penn, JL Parent, AN Pronin, RA Panettieri… - … of Pharmacology and …, 1999 - ASPET
The use of pharmacological inhibitors of protein kinases represents a potentially powerful
tool in dissecting the regulatory features of intracellular signaling pathways. However, …
tool in dissecting the regulatory features of intracellular signaling pathways. However, …
[HTML][HTML] Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
…, RR Lavoie, JM Lacroix, S Roy, JL Parent… - Nature …, 2017 - nature.com
The pH-dependent partitioning of chemotherapeutic drugs is a fundamental yet understudied
drug distribution mechanism that may underlie the low success rates of current approaches …
drug distribution mechanism that may underlie the low success rates of current approaches …
[HTML][HTML] Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: identification of a distinct motif for tonic internalization
JL Parent, P Labrecque, MD Rochdi… - Journal of Biological …, 2001 - ASBMB
The thromboxane A 2 receptor (TP) is a G protein-coupled receptor that is expressed as two
alternatively spliced isoforms, α (343 residues) and β (407 residues) that share the first 328 …
alternatively spliced isoforms, α (343 residues) and β (407 residues) that share the first 328 …
Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity
…, K Radde-Gallwitz, F Chi, JL Parent… - Proceedings of the …, 2011 - National Acad Sciences
The vertebrate planar cell polarity (PCP) pathway shares molecular components with the β-catenin–mediated
canonical Wnt pathway but acts through membrane complexes containing …
canonical Wnt pathway but acts through membrane complexes containing …
Production of Prostaglandin D2 by Human Osteoblasts and Modulation of Osteoprotegerin, RANKL, and Cellular Migration by DP and CRTH2 Receptors
…, JA Hackett, J Antoniou, JL Parent… - Journal of Bone and …, 2005 - academic.oup.com
Human osteoblasts produce PGD 2 , which acts on the DP receptor to decrease osteoprotegerin
production and on the CRTH2 receptor to decrease RANKL expression and to induce …
production and on the CRTH2 receptor to decrease RANKL expression and to induce …