Radioisotopic assays involve expense, multistep protocols, equipment, and radioactivity safety
requirements which are problematic in high-throughput drug testing. This study reports an …

The prevalence of DSM-III disorders was studied in 943 adolescents aged 15 years from a
general population. Prevalence rates of disorder of 25.9% for girls and 18.2% for boys were …

The goal for developing new antimalarial drugs is to find a molecule that can target multiple
stages of the parasite’s life cycle, thus impacting prevention, treatment, and transmission of …

Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial
drug development. Monotherapy and highly mutable drug targets have each facilitated …

In the present article we examine the antiplasmodial activities of novel quinolone derivatives
bearing extended alkyl or alkoxy side chains terminated by a trifluoromethyl group. In the …

A class of hybrid molecules which we term ‘reversed chloroquines' (RCQs) was designed,
and a prototype molecule, N‘-(7-chloroquinolin-4-yl)-N-[3-(10,11-dihydrodibenzo[b,f]azepin-5-…

Prodiginines are a family of linear and cyclic oligopyrrole red-pigmented compounds. Herein
we describe the in vitro antimalarial activity of four natural (IC 50 = 1.7–8.0 nM) and three …

The kind of house we live in and its location is of fundamental importance to us. It affects our
everyday lives in a multitude of ways: the length of the daily commute; our choices about …

Donor treatment with granulocyte-colony-stimulating factor (G-CSF) attenuates the ability of
donor T cells to induce acute graft-versus-host disease (aGVHD) but increases the severity …

Background. The human immunodeficiency virus (HIV) care continuum has become an
important tool for evaluating HIV care. Current depictions of the care continuum are often cross-…