Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs.
The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive …

… , orthopedic surgery and collection for research; J. Steinmeyer, tissue preparation for
experiments; SG, project design and experimental design; J. Schölmerich, project and experimental …

Alleviation of pain and inhibition of inflammation are the primary goals of pharmacotherapy
of osteoarthritis (OA). These therapeutic goals can almost always be accomplished by the …

Cartilage defects occur in approximately 12% of the population and can result in significant
function impairment and reduction in quality of life. Evidence for the variety of surgical …

Objective Membrane phospholipid species contribute to boundary lubrication that is provided
by synovial fluid (SF). Altered levels of lubricants can be associated with increased friction, …

Background Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute
independently or together to the boundary lubrication of articular joints that is provided by synovial …

Introduction Rheumatoid arthritis synovial fibroblasts (RASF) are key players in synovial
pathophysiology and are therefore examined extensively in various experimental approaches. …

Objective Rheumatoid arthritis (RA) is associated with increased production of adipokines,
which are cytokine‐like mediators that are produced mainly in adipose tissue but also in …

Articular synovial fluid (SF) is a complex mixture of components that regulate nutrition,
communication, shock absorption, and lubrication. Alterations in its composition can be pathogenic…

A split aptamer for adenosine triphosphate (ATP) was embedded as a recognition unit into
two levers of a nanomechanical DNA origami construct by extension and modification of …