Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the attachment …

Normal hemostasis is initiated by damage of the vessel wall with exposure of subendothelial
structures to flowing blood and results in the formation of a solid hemostatic plug. The first …

Platelet activation leads to secretion of granule contents and to the formation of microvesicles
by shedding of membranes from the cell surface. Recently, we have described small …

… Netherlands, Tel: +3 1-30-250-77 -69; Fax: +3 1 -30-251-18-93; Em ail j sixma@ lab.azu.nl …
Platelet adhesion in flow to collagen tpe I J[I, IV and VI is also dependent on vWF. Adhesion …

ONE of the early events in the haemostatic process is the adherence of blood platelets to
collagen of the subendothelium. Subsequent platelet-to-platelet adhesion then leads to the …

Transient interactions of platelet-receptor glycoprotein Ibα (GpIbα) and the plasma protein
von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a …

The interaction of blood platelets with collagen is generally considered to be of primary
importance in the arrest of bleeding and to have a role in the pathogenesis of thrombosis and …

To clone the CD63 antigen, originally described as a blood platelet activation marker, we
adapted the expression cloning procedure of Seed and Aruffo (Seed, B., and Aruffo, A. (1987) …

… Hirsh J: Enhanced platelet accumulation into carotidic arteries in rabbits following aspirin
treatment. J Clin Invest 1981;67:503-508 31. Nievelstein PFEM, D'Allessio P, …

Hematocrit and vessel wall shear rate are important factors in the transport and subsequent
adherence of platelets to vessel wall subendothelium. When mass transport theory is …