… ‘139 In studies where SJL/J mice were tolerized against either PLP … Only tolerization with
PLP peptides protected SJL/J mice … For instance, in SJL/ J mice the encephalitogenic peptide is …

Objectives: To review the role of T lymphocytes in the pathogenesis of rheumatoid arthritis (RA)
and discuss the relevance of the components of the trimolecular complex (synovial T cells…

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS).
Significant progress has been made in our understanding of the etiology of MS. MS is …

Equal numbers of CD4+ T cells recognizing myelin basic protein (MBP) and proteolipid
protein (PLP) are found in the circulation of normal individuals and multiple sclerosis (MS) …

Several studies have reported a suppressed immune function (eg blast transformation) during
depression. In an attempt to define the cellular basis of the reported immune disorders, the …

In an attempt to delineate the pathophysiology underpinning the previously reported blunted
lymphocyte responses to mitogenic stimulation in depressed patients, we measured the …

Osteoporotic fragility fractures are related to bone density and injury, which are both related
to muscle strength. The influence of genetic factors, such as the vitamin D receptor (VDR) …

Accumulating evidence indicates an immunosuppressive role for CD4 + CD25 + regulatory
T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with …

We determined the following immune parameters in drug-free, major depressed patients
and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 …

Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks.
Experimental autoimmune diseases can be treated by inoculation with autoreactive T …