In clinical measurement comparison of a new measurement technique with an established
one is often needed to see whether they agree sufficiently for the new to replace the old. Such …

Statistics Notes Page 1 are successful doctors may then be prepared to invest more time in
them. Further consideration should be given to new ways that general practitioners can deliver …

Agreement between two methods of clinical measurement can be quantified using the
differences between observations made using the two methods on the same subjects. The 95% …

Methods of analysis used in the comparison of two methods of measurement are reviewed.
The use of correlation, regression and the difference between means is criticized. A simple …

Many quantities of interest in medicine, such as anxiety or degree of handicap, are impossible
to measure explicitly. Instead, we ask a series of questions and combine the answers into …

Many published papers include large numbers of significance tests. These may be difficult to
interpret because if we go on testing long enough we will inevitably find something which is …

When comparing a new method of measurement with a standard method, one of the things
we want to know is whether the difference between the measurements by the two methods is …

We often want to compare two estimates of the same quantity derived from separate analyses.
Thus we might want to compare the treatment effect in subgroups in a randomised trial, …

Limits of agreement provide a straightforward and intuitive approach to agreement between
different methods for measuring the same quantity. When pairs of observations using the two …

The whole point of a diagnostic test is to use it to make a diagnosis, so we need to know the
probability that the test will give the correct diagnosis. The sensitivity and specificity 1 do not …